On Wednesday, towards the conclusion of the 3-hour debate aired on CNN, Coulter went off on a Twitter rant taking the Republican candidates to task for their expressions of support of Israel, ending with, “How many f—ing Jews do these people think there are in the United States?”

“How to get applause from GOP donors: 1) Pledge to start a war 2) Talk about job creators 3) Denounce abortion 4) Cite Reagan 5) Cite Israel,” Coulter continued her rant, even after being called out for Twitter users.

She refused to walk back the tweet later on in an appearance on Fox News Channel’s “The Kelly File.”

“I was tweeting all night and all the candidates were pandering, pandering, pandering,” Coulter said. “I wrote my column about it. They seem to be hitting certain boxes. Have to mention Reagan, have to mention that they’re pro-life, have to mention Israel. The entire Republican Party is pro-Reagan, pro-life, pro-Israel. The last question was, ‘After your president, how will America be better?’ And suddenly we’re back to Israel again. It’s just this checking off of the boxes and the virtue boxes. And it’s one of the things I like about – and in fact, I think they’re probably pandering, which was the subsequent tweet — they’re probably pandering to evangelicals, not Jews. But it’s just pandering, pandering, pandering — something we all agree on.”

Coulter’s comments encouraged an anti-Semitic and anti-Israel discussion on twitter under the hashtag #IStandwithAnn.

In response, the National Jewish Democratic Council issued the following statement, seeking to answer Coulter’s query.

“Ms. Coulter, since you asked so nicely, there are approximately 6.5 million Jews living in the United States. Furthermore, the vast majority of that population voted for President Obama in 2012, and we will continue to vote for Democratic candidates in 2016 and beyond,” NJDC chair Greg Rosenbaum stated. “After hearing 15 conservative Republican candidates praise failed foreign policies that, among other horrendous consequences, damaged Israel and the vital alliance between the US and Israel; attack those seeking to marry the people they love while defending the right to discriminate against them; demonize an organization that provides crucial health care to women in need; deny the existence of climate change exactly when scientists found 2015 to be the warmest year in our planet’s recorded history; and dangerously spread the lie that vaccinations are tied to autism, we have no doubt that the American Jewish community will remain overwhelmingly with the Democratic party.”

“Perhaps, Ann, you did not get the memo from GOP headquarters that Israel is supposed to be a partisan wedge issue, designed to peel off Jewish voters from the Democratic Party. After all, putting partisan politics over good policy, your party’s legislators unanimously opposed the world’s agreement with Iran to prevent it from acquiring a nuclear weapon. But don’t worry, Ann. Disgusting anti-Semitic comments like yours will help maintain the traditional bonds between American Jewish voters and their home in the Democratic Party, where they are actually welcome,” he added.

Coulter is currently supporting Donald Trump for president.

Ironically, Iran’s Supreme Leader Ayatollah Ali Khamenei joined Coulter in lamenting “presidential candidates try to satisfy Zionists.”

“US govs put their people under Zionists custody. Isn’t it a shame that presidential candidates try to satisfy Zionists&prove their servitude?” Khamenei tweeted on Thursday.

“Zionist regime is an imposed regime, made through coercion; no entity made by coercion would last. This regime will not survive either,” he added.

The Anti-Defamation League (ADL) derided Coulter’s series of tweets as “ugly, spiteful and borderline anti-Semitic.”

In a statement issued on Thursday, ADL’s national director Jonathan Greenblatt said, “While most of America has rightly tuned out Ann Coulter’s hyperbolic and hateful rhetoric, her irresponsible tweets during the Republican presidential candidate’s debate are truly a new low and must be called out. Ms. Coulter is pandering to the basest of her base. Her messages challenging the candidates’ support for Israel were offensive, ugly, spiteful and borderline anti-Semitic. Her tweets give fodder to those who buy into the anti-Semitic notions that Jews “control” the U.S. government, wield disproportionate power in politics, and are more loyal to Israel than to their own country.”