Three House Democrats from New York and a House Democrat from Florida who is running for a Senate seat endorsed President Obama’s nuclear deal with Iran on Monday, lending fresh momentum to the pact from political quarters that once appeared most leery of it.

In rapid succession, Representatives Nydia M. Velázquez, Gregory W. Meeks and Yvette Clarke of New York backed the deal, as did Representative Patrick Murphy, the Democratic establishment’s choice to compete for the Senate seat being vacated by the Republican presidential candidate Marco Rubio. Mr. Murphy’s decision was the most surprising: Democratic leaders supporting the deal had written him off as he battles Representative Alan Grayson, a liberal who is leaning against the accord, for his party’s Senate nomination.

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