Glioblastoma is the most aggressive form, with majority of patients usually dying within 1 year of diagnosis

Tel Aviv University (TAU) announced a major breakthrough Sunday in understanding and treating one of the most aggressive forms of brain cancer - Glioblastoma.

"Glioblastoma is the deadliest type of cancer in the central nervous system, accounting for most malignant brain tumors," said  Prof Ronit Satchi-Fainaro, Director of the Cancer Biology Research Center and the Head of the Cancer Research and Nanomedicine Laboratory at Tel Aviv University's Sackler Faculty of Medicine.

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"It is aggressive, invasive, and fast-growing, making it resistant to existing treatments, with patients dying within a year of the cancer's onset. Moreover, Glioblastoma is defined as a 'cold tumor', which means that it does not respond to immunotherapeutic attempts to activate the immune system against it," she added.

Initially, the researchers identified an unusual failure in the brain's immune system, which not only did not inhibit the cancer, it actually amplified the cell division and spread of Glioblastoma cancer cells. This is due to the presence of a protein - P-Selectin (SELP).

Researchers were able to inhibit the secretion of the SELP protein, thereby neutralizing the failure in the immune system, restoring its normal activity, and blocking the spread of this incurable cancer. Read more at i24